Mannitol Injection, USP, 25%, an osmotic diuretic, is a sterile, nonpyrogenic solution of mannitol in Water for Injection. It is a supersaturated solution at room temperature. Each mL contains: Mannitol 250 mg; Water for Injection q.s. The osmolar concentration is 1372 mOsmol/L (calc.). It contains no antimicrobial agents. Mannitol Injection, USP, 25% is indicated for the following therapeutic uses: - in the prophylaxis of oliguria in surgical procedures and traumatic conditions involving renal insult; - in the adjuvant treatment of oliguria or anuria; - the promotion of diuresis in the supportive treatment of edema and ascites; - the reduction of elevated cerebrospinal fluid pressure; - in the adjunctive treatment in certain drug intoxications.
